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Calcium carbonate is approved as an active ingredient in antacid, in section 21 CFR 331.10 of the Code of Federal Regulations. Each suggested single dosage unit must contain at least 5 mEq (milliequivalents) of acid neutralizing capacity.[32] Calcium based antacid are not recommended since they stimulate the release of the hormone gastrin in stomach and duodenum which in turn is responsible for stimulation of acid secretion. The over production of acid is counterproductive for the treatment of GERD.[33] Calcium antacid are so efficient at neutralizing acid that the stomach thinks a LOT of food must have arrived and puts out more acid (called rebound hyper acidity), if it can. This often leads to antacid addiction--you are taking more and more antacid over time to get the same results.[34]

[32] http://www.specialtyminerals.com/specialty-applications/specialty-markets-for-minerals/pharmaceuticals/antacids/

[33] http://www.omnimedicalsearch.com/conditions-diseases/gerd-treatment-prevention-options.html

[34] http://www.gentlebirth.org/archives/antacids.html

Magnesium hydroxide and aluminium hydroxide are the most potent magnesium and aluminium salts and are often used in combination. In addition, magnesium oxide, magnesium carbonate, aluminium phosphate, magaldrate, magnesium tri silicate, and aluminium sucrose sulphate (sucralfate) are also employed.[40] Magnesium salts offered in combination products with aluminium (Mylanta and Maalox) balance the side effects of diarrhoea and constipation. [41] Magnesium Hydroxide, found in Mylanta, can also reduce absorption of potassium in your intestines. So, people who use these antacid on a regular basis may need to take a potassium supplement.[42]

[40] http://www.ehealthproduct.com/health-care/digestive-health/antacids/

[41] http://www.healthcentral.com/acid-reflux/introduction-000085_10-145.html

[42] http://www.helium.com/items/1025371-otc-antacids-or-acid-reducers-what-you-should-know

Magnesium has a mild laxative effect; it can cause diarrhea. For this reason, magnesium salts are rarely used as the only active ingredients in an antacid, but are combined with aluminium, which counteracts the laxative effect.[43]

[43] http://www.fda.gov/bbs/topics/consumer/con00120.html

 

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