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Aciphex is a proton pump inhibitor and, with annual sales of about $1.2 billion last year, it accounts for over 40% of Eisai's total U.S.drug sales. ACIPHEX is also used in adults for the short-term (4 to 8 weeks) treatment in the healing and symptom relief of damaging (erosive) acid reflux disease (gastroesophageal reflux disease). The most common side effect possibly related to ACIPHEX is headache. Aciphex is outrageously expensive-a lot of complaints I read stated that. Many said it helped, but they couldn't afford to stay on it.

PPI: (Proton Pump Inhibitors).

Proton pump inhibitors are safe, although they may be expensive, especially if taken for a long period of time. Long-term risks of PPIs may include an increased risk of gut infections, such as Clostridium (C.[4] Proton pump inhibitors have enabled improved treatment of various acid-peptic disorders, including gastroesophageal reflux disease, peptic ulcer disease, and non steroidal anti-inflammatory drug induced gastropathy. Proton pump inhibitors have minimal side effects and few significant drug interactions, and they are generally considered safe for long-term treatment.[5]

[4] http://patients.uptodate.com/topic.asp?file=digestiv/7771&title=barrett's+esophagus&session=xx7jvcrt0ofmbyu0afnqnukmf8

[5] http://www.aafp.org/afp/20020715/273.html

Antacid:

Antacid are fast-acting and should provide relief within minutes. If you are taking antacid and you do not find relief, something else may be causing your problems.[1] Antacid are taken by people who are already suffering from heartburn or GERD. They give prompt relief from acid burning unprotected tissue.[2] Antacid are widely used in the management of duodenal ulcer but the optimum dose of antacid required for ulcer healing has not been determined. We therefore studied 107 patients with endoscopically diagnosed duodenal ulcer who were allotted at random to one of the following treatment groups; placebo (group P) and antacid (groups A, B and C).[3]

[1] http://gerd.emedtv.com/antacids/antacids.html

[2] http://home.hvc.rr.com/bobcotton/gerdsalt.htm

[3] http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1432306

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